Banca de QUALIFICAÇÃO: TIAGO NOVAIS ROCHA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : TIAGO NOVAIS ROCHA
DATE: 19/11/2019
TIME: 15:30
LOCAL: FACISA
TITLE:

THE ROLE OF MULTIPARITY AND MATERNAL AGE AT FIRST CHILD IN THE ASSOCIATION BETWEEN EARLY MENARCHE AND METABOLIC SYNDROME IN MIDDLE AND OLDER WOMEN

KEY WORDS:

Menarche. Women. Risk factors. Metabolic syndrome. Pregnancy.

PAGES: 29
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Introduction: Metabolic syndrome (MS), an indicator of increased cardiovascular risk and a frequent condition at older ages. However, it is known to be associated with factors present in the early stages of life, such as the occurrence of early menarche. Other factors of reproductive history (age at first child and parity) are also associated with increased cardiovascular risk in women and the role of these factors in the relationship between early menarche and MS has not been studied. Understanding the pathways linking early menarche with MS can help shape health strategies to reduce cardiovascular risk in women. Objective: To analyze the relationship between early menarche and MS in middle-aged and older women, and to verify whether maternal age at first child and parity are mediators of this relationship. Methods: This study is characterized by being of observational cross-sectional analytical type, composed of 451 women aged 40 to 80 years. Age at first birth, parity, and early menarche (≤ 11 years) were assessed by self-report, and MS was assessed by the presence of at least 3 of the following criteria: high blood pressure, triglycerides ≥150mg/dl, HDL <50mg/dl, fasting glucose >100mg/dl, and waist circumference >88cm. The relationship between MS and early menarche was assessed by binary logistic regression analysis adjusted for the covariates age, smoking, family income, education and physical exercise. The role of age at first birth and multiparity on the relationship between early menarche and MS was assessed by means of the mediation analysis adjusted by the same covariates. Results: There was an association between early menarche and MS (OR: 2.294; p <0.05) indicating that early menarche increases twice the chance of a woman presenting MS at older ages. Through the mediation analysis it was possible to verify that the menarche has a direct effect on MS (Effect: 0.8043 CI: 0.1035; 1.5050), and of the two potential mediators, only the maternal age to the first child was a significant pathway (Effect: 0.0666 IC: 0.0014; 0.2171).

BANKING MEMBERS:
Presidente - 3885543 - SAIONARA MARIA AIRES DA CAMARA
Interna - 2211023 - ILLIA NADINNE DANTAS FLORENTINO LIMA
Externo ao Programa - 1674532 - DIMITRI TAURINO GUEDES