EFFECTS OF tDCS IN PATIENTS WITH DIABETIC POLYNEUROPATHY
Diabetic neuropathy. Hyperalgesia. Analgesia.
Diabetes mellitus is a chronic disease characterized by peripheral nerve injury and neuropathic pain. This disease affect several organs and systems and can generate serious vascular complications, being the main cause of painful diabetic polyneuropathy (PDP). This is characterized by constant pain that affect the quality of life and functionality in diabetic patients. The treatment is a challenge for the health professional team, since in some cases, the pain presents no significant pattern of improvement or is partially resolved with medications. Recent studies have reported that central neuropathic mechanisms may contribute to painful processes in diabetic patient due to thalamic dysfunction. Since the CNS is involved in the pathogenesis of neuropathic pain, transcranial direct current stimulation (tDCS) can modulate the neuronal circuitry involved in the process, promoting reduction of the pain symptom. tDCS is a noninvasive neuromodulation technique that uses electrical current administered through the scalp to the nervous tissue, generating changes in cortical excitability according to stimulation parameters. It is suggested that the application of the tDCS promotes therapeutic benefits for several populations with chronic pain, thus being a tool of easy application and low cost when compared to other therapeutic modalities. However, it is necessary study the parameters, the electrode placement sites and the time of therapy in order to present the best form of application. Objectives: To verify the effects of 5 applications of 2mA anodal tDCS for 20 min. over the primary motor cortex (M1) on pain and functionality in patients with diabetic polyneuropathy. Materials and Methods: This is a double blind randomized trial with 20 patients of both genders aged 18 to 80 years with diagnosis of PDP. Groups will be divided into M1 group and Sham. The evaluation includes Body Mass Index, Blood Pressure, Blood Glucose, arm ankle index, quality of life questionnaire, physical activity and 6-minute stress test. It will be performed evaluation before the intervention and two follow-ups (14 and 21 days). Data analysis: SPSS 20.0 software will be used for statistical analysis. Shapiro Wilk test, mixed ANOVA and their respective post tests will be applied to detect the occurrence of significant differences between the intervention and sham group. Spearman correlation test will also be applied. For all tests, the significance level of P less than or equal to 0.05% will be considered.